Amlodipine: What It Does and What You Should Know

Amlodipine is a common blood pressure pill that relaxes blood vessels so blood flows easier. People take it for high blood pressure and to ease chest pain (angina). It works slowly and is taken once a day, which makes it easy to fit into your routine.

How to take amlodipine

Take amlodipine at the same time every day, with or without food. Typical starting doses are 2.5–5 mg once daily for adults, and doctors may raise it to 10 mg if needed. Don’t crush or split extended-release versions unless your pharmacist says it’s okay. If you miss a dose, take it as soon as you remember unless it’s close to the next dose — don’t double up.

Keep using it even if you feel fine. High blood pressure often has no symptoms, so stopping suddenly can raise risks for heart attack or stroke. If you plan to stop or change dose, talk with your doctor so they can guide a safe plan.

Watch for these side effects & interactions

The most common side effects are ankle swelling (edema), flushing, dizziness, and feeling tired. Swelling usually shows up in the feet and lower legs and isn’t always dangerous, but tell your doctor if it gets worse or comes with shortness of breath.

Serious reactions are rare but can include very low blood pressure, fainting, or an allergic reaction. If you feel chest pain that changes, sudden fainting, severe dizziness, or trouble breathing, get medical help right away.

Amlodipine can interact with other drugs. Grapefruit and grapefruit juice can increase levels of some calcium channel blockers and may raise side effects. Also be careful with strong CYP3A4 inhibitors (like certain antifungal or antibiotic drugs) and some blood pressure medicines — combining them can lower blood pressure too much. Tell your doctor about all medicines and supplements you take.

Measure your blood pressure at home when starting or changing dose so you can see how it’s working. Weigh yourself weekly to check for fluid gain. If you notice sudden swelling, rapid weight gain, or increased shortness of breath, contact your provider.

Simple habits make a difference: stand up slowly to avoid dizziness, avoid heavy drinking that can drop your blood pressure, and store the pills at room temperature away from moisture. Keep medical ID info handy if you’re on multiple heart meds.

If you want alternatives, medicines like nifedipine (a related calcium channel blocker), ACE inhibitors, ARBs, or beta blockers may be options depending on your health. The right choice depends on your heart, kidneys, and other meds — so work with your doctor to pick the safest plan.

Have questions about side effects, dose changes, or mixing amlodipine with other treatments? Ask your clinician — they can tailor advice to your situation and help you stay safe while controlling your blood pressure.