Aromatase Inhibitors: What They Are, How They Work, and What You Need to Know

When you hear aromatase inhibitors, drugs that stop the body from turning androgens into estrogen. Also known as AI, they’re not just for breast cancer—they’re used in bodybuilding, hormone therapy, and even fertility treatments. These drugs work by blocking the enzyme aromatase, which turns testosterone and other male hormones into estrogen. Less estrogen means fewer side effects like gynecomastia, water retention, and fat gain—especially for men on testosterone therapy.

There are three main aromatase inhibitors, medications that reduce estrogen levels by inhibiting the aromatase enzyme. Also known as AIs, they: anastrozole, letrozole, and exemestane. Anastrozole is the most common in cancer care and is often used at 0.5–1 mg per day. Letrozole is stronger and used for more aggressive estrogen control, while exemestane is a steroidal AI that can have a slightly different side effect profile. Each has its own use case, and choosing the right one depends on your goals, health history, and tolerance.

People using these drugs often deal with joint pain, bone thinning, hot flashes, and fatigue—side effects tied to low estrogen. That’s why many combine them with calcium, vitamin D, and weight training to protect bones. Some even cycle them to avoid long-term suppression. You’ll find real-world advice on managing these issues in the posts below, including how to handle anastrozole joint pain without quitting treatment.

These aren’t over-the-counter supplements. They’re prescription drugs with real risks. But they’re also one of the most effective tools we have for controlling estrogen when it’s out of balance. Whether you’re a patient on cancer therapy, an athlete managing hormone levels, or just trying to understand why your doctor recommended one—you’ll find clear, no-fluff guidance in the articles ahead. No marketing hype. Just what works, what doesn’t, and how to stay safe.

Martin Kelly 16 November 2025 12

Hormone Therapy for Breast Cancer: Tamoxifen vs Aromatase Inhibitors Explained

Tamoxifen and aromatase inhibitors are key treatments for hormone receptor-positive breast cancer. Learn how they work, their benefits, side effects, and how to choose the right one based on menopause status, risk, and personal health.